Every Little Step Counts: Efficacy Trial

Every Little Step Counts: Efficacy Trial

Funding: National Institutes of Health/National Institute on Minority Health and Health Disparities, center grant award P20 MD002316 NIMHD (2012-2017)

This study, using a randomized-controlled trial, tests the efficacy of  a culturally-grounded, community-based diabetes prevention program to increase insulin sensitivity and weight-specific quality of life in 160 obese Latino adolescents. The study also explores potential mediators and moderators of the intervention’s effects and estimates the initial incremental cost-effectiveness of the intervention for increasing insulin sensitivity. The intervention is guided by Social Cognitive Theory and framed within a multilevel ecodevelopmental model to address surrounding contextual factors that are thought to influence health behaviors and health outcomes in obese Latino youth during a critical life period. The project builds upon extant collaborations of a transdisciplinary team of investigators with the community to address critical gaps in how prevention interventions for obese Latino youth are developed, implemented and evaluated. This innovative approach is an essential step in the development of cost-effective, solution-oriented programs to improve the health of Latino youth.

Updates:

• Enrollment and data collection are complete.
• Data cleaning and analysis are underway.
• Additional funding has been secured to adapt and evaluate the intervention for obese Latino youth with prediabetes. (NIH/NIDDK - R01 DK107579)
• Additional funding has been secured to further refine and test the feasibility, acceptability, and preliminary efficacy among Latino families in Maryvale, AZ. (Az Dept Health Services ADHS16-105121)

Brito, E., Patrick, D. L., Konopken, Y. P., Keller, C. S., Barroso, C. S., & Shaibi, G. Q. (2013). Effects of a diabetes prevention program on weight-specific quality of life in Latino youth. Pediatric Obesity. Advance online publication. doi: 10.1111/ijpo.240  Read online PMCID: PMC4163087 ‡

Castro, F. G., Shaibi, G. Q., & Boehm-Smith, E. (2009). Ecodevelopmental contexts for preventing Type 2 diabetes in Latino and other racial/ethnic minority populations. Journal of Behavioral Medicine, 32, 89-105. doi: 10.1007/s10865-008-9194-z. ‡ Read online PMCID: PMC2798813

Miranda, D. N., Coletta, D. K., Mandarino, L. J., & Shaibi, G. Q. (2014). Increases in insulin sensitivity among obese youth are associated with gene expression changes in whole blood. Obesity, 22(5):1337-44. doi: 10.1002/oby.20711 ‡ Read online PMCID: PMC4008712

Ryder, J. R., Vega-López, S., Gaesser, G. A., Buman, M. P., & Shaibi G. Q. (2014).  Heterogeneous vascular responses to lifestyle intervention in obese Latino adolescents. Metabolic Syndrome and Related Disorders, 12(10), 509-15. doi: 10.1089/met.2014.0060 ‡  PMCID: 25162989.

Ryder, J. R., Vega-López, S., Djedjos, C. S., & Shaibi, G. Q. (2013). Abdominal adiposity, insulin resistance, and oxidized low-density lipoproteins in Latino adolescents. Diabetology & Metabolic Syndrome, 5: 72.  doi: 10.1186/1758-5996-5-72 Read online PMCID: PMC3832228 ‡

Ryder, J. R., Vega-López, S.,, Ortega, R., Konopken, Y., & Shaibi, G. Q. (2013). Lifestyle intervention improves lipoprotein particle size and distribution without weight-loss in obese Latino adolescents. Pediatric Obesity, 8(5), E59-E63. doi: 10.1111/j.I2047T-6310.201Y3.00162.x ‡ Read online PMCID: PMC3898800

Shaibi, G. Q., Konopken, Y. P., Nagle-Williams, A., McClain, D. D., Castro, F. G., & Keller, C. S. (2015). Diabetes prevention for Latino youth: Unraveling the intervention “black box.” Health Promotion Practice, 16(6), 916-24. ‡ doi:10.1177/1524839915603363

Shaibi, G. Q., Ryder, J. R., Kim, J. Y., & Barraza, E. (2015). Exercise for obese youth: Refocusing attention from weight loss to health gains. Exercise and Sport Sciences Reviews, 43(1), 41-47. doi: 10.1249/JES.0000000000000034. PMCID: PMC4317400 ‡

Shaibi, G. Q., Konopken, Y., Ortega, R., Hoppin, E., Keller, C. S., & Castro F. G. (2012). Effects of a culturally-grounded community-based diabetes prevention program for obese Latino adolescents. The Diabetes Educator, 38, 504-512.  doi: 10.1177/0145721712446635 ‡ Read online PMCID:PMC3840126

Shaibi, G. Q., Greenwood-Ericksen, M. B.., Chapman, C. R., Konopken, Y., & Ertl, J. (2010). Development, implementation, and effects of community-based diabetes prevention program for obese Latino youth. Journal of Primary Care and Community Health, 1, 3, 206–212.  doi: 10.1177/2150131910377909. ‡ Read online PMCID: PMC3068841

 

Other related publications

Brickey, S. R., Ryder, J. R., McClellan, D. R., Shaibi, G. Q. (2014). Soluble receptor for advanced glycation end products independently predicts cardiometbaolic syndrome in Latino youth. Pediatric Diabetes, 6, 403-407. doi: 10.1111/pedi.12095

Davis, J. N., Ventura, E. E., Shaibi, G. Q., Byrd-Williams, C. E., Alexander, K. E., Vanni, A. K., Meija, M. R., Weigensberg, M. J., Spruijt-Metz, D., & Goran, M. I. (2010). Interventions for improving metabolic risk in overweight Latino youth. International Journal Pediatric Obesity, 5, 451-455. doi: 10.3109/17477161003770123 Read online PMCID: PMC3752963

DeMenna, J., Puppala, S., Chittoor, G., Schneider, J., Kim, J. Y., Shaibi, G. Q., Mandarino, L. J., Duggirala, R., Coletta, D. K. (2014). Association of common genetic variants with diabetes and metabolic syndrome related traits in the Arizona insulin resistance registry: A focus on Mexican American families in the Southwest. Hum Hered, 78(1):47-58. doi: 10.1159/000363411

González-García, Z. M., Kullo, I. J., Coletta, D. K., Mandarino, L. J., & Shaibi, G. Q. (2015). Osteocalcin and type 2 diabetes risk in Latinos: A life course approach. American Journal of Human Biology, 27(6), 859-861.

Greenwood-Ericksen, M. B., Chapman, C. R., Konopken, Y., Ertl, J., & Shaibi, G. Q. (2010). Sustainability of a culturally informed community-based diabetes prevention program for obese Latino youth. Journal of Primary Care & Community Health, 1(2), 83-87. doi: 10.1177/2150131910368864. Read abstract

Hawthorne, A., Shaibi, G. Q., Gance-Cleveland, B., & McFall, S. (2011). Grand Canyon Trekkers: School-based lunchtime walking program. The Journal of School Nursing, 27, 43-50. doi: 10.1177/1059840510391669 Read abstract PMID: 21123848

Hizon, M. C., Kapadia, C., Garcia-Fillion, P., McCkekkan, D., & Shaibi, G. Q. (2013). Is A1C less concordant with OGTT in children as compared in adults? Data from a Hispanic community in Arizona. Journal of Diabetes & Metabolism, 4(7), 290. doi:10.4172/2155-6156.1000290

Hudson, O., Nunez, M, & Shaibi, G. Q. (2012). Ethnicity and elevated liver transaminases among newly diagnosed children with Type 2 diabetes. BMC Pediatrics, 12, 174. doi: 10.1186/1471-2431-12-174 Read online PMCID: PMC3534506

Flores, Y. N., Shaibi, G.Q., Morales, L. S., Salmerón, J., Skalicky, A. M., Edwards, T.C.,…Patrick D. L. (2015). Perceived health status and cardiometabolic risk among a sample of youth in Mexico. Qual Life Res, 24(8), 1887-1897.

Keller, C., Coe, K., & Shaibi, G. (2015). Using Rituals for Intervention Refinement. Health, Culture and Society, 8(2), 37.

Kim, J. Y., Campbell, L. E., Shaibi, G. Q., & Colletta, D. K. (2015). Gene expression profiling and association of circulating lactoferrin level with obesity-related phenotypes in Latino youth. Pediatric Obesity, 10(5), 338-344. doi: 10.1111/ijpo.269

Kim, J. Y., Goran, M. I., Toledo-Coral, C. M, Weigensberg, M. J., & Shaibi, G. Q. (2015).  Comparing glycemic indicators of prediabetes: A prospective study of obese Latino youth. Pediatric diabetes, 16(8), 640-643. doi: 10.1111/pedi.12225

Kim, J., Goran, M., Toledo-Coral, C., Weigensberg,M. J., Choi,  M., & Shaibi, G. Q. (2013). One hour glucose during an oral glucose challenge prospectively predicts β-cell deterioration and prediabetes in youth. Diabetes Care, 36(6), 1681-6. doi: 10.2337/dc12-1861 Read online PMCID: PMC3661793

Kim, J., Coletta, D., Mandarino, L. J., & Shaibi, G. Q. (2012). Glucose response curve and Type 2 diabetes risk in Latino adolescents. Diabetes Care, 35, 9, 1925-1930. doi: 10.2337/dc11-2476 Read online PMCID: PMC3424993

Melnyk, B.,  Jacobson, D., Kelly, S., Belyea, M., Shaibi, G., Small, L., O’Haver, J., & Marsiglia, F. F. (2013). Promoting healthy lifestyles in high school adolescents: A randomized controlled trial.  American Journal of Preventive Medicine, 45, 407-415. doi: 10.1016/j.amepre.2013.05.013 Read online PMCID: PMC4285557

Melnyk, B. M., Kelly, S., Jacobson, D., Belyea, M., Shaibi, G. Q., Small, L., O’Haver, J., & Marsiglia, F. F. (2013). The COPE Healthy Lifestyles TEEN randomized controlled trial with culturally diverse high school adolescents: Baseline characteristics and methods. Contemporary Clinical Trials, 36, 41-53.  doi: 10.1016/j.cct.2013.05.013 Read online PMCID: PMC4293700

Melnyk, B. M., Jacobson, D., Kelly, S., Belyea, M., Shaibi, G., Small, L.,O’Haver, J. A., & Marsiglia, F. (2015). Twelve-month effects of the COPE healthy lifestyles TEEN program on overweight and depressive symptoms in high school adolescents. Journal of School Health, 85, 861-870. doi: 10.1111/josh.12342

Melnyk, B. M., Kelly, S., Jacobson, D., & Shaibi, G. Q. Small, L., O'Haver, J., & Marsiglia, F. F. (2013). Improving healthy behaviors, bmi, psychosocial & academic outcomes:  A RCT test of COPE TEEN in high school adolescents. American Journal of Preventive Medicine, 45(4), 407-15. doi: 0.1016/j.amepre.2013.05.013

Rosen, G., Beebe, K. L., & Shaibi, G. Q. (2013). Vitamin D levels differ by cancer diagnosis and decline over time in survivors of childhood cancer. Pediatric Blood and Cancer, 60(6), 949-52. doi: 10.1002/pbc.24349

Rosen, G. P., Nguyen, H. T., & Shaibi, G. Q. (2013). Metabolic syndrome in pediatric cancer survivors: A mechanistic review. Pediatric Blood and Cancer, 60(12), 1922-8. doi: 10.1002/pbc.24703

Shaibi, G. Q., Coletta, D. K., Vital, V., & Mandarino, L. J. (2013). The design and conduct of a community-based registry and biorepository: A focus on cardiometabolic health in Latinos. Clinical and Translational Science, 6(6), 429-434. doi: 10.1111/cts.12114

Shaibi, G. Q., Davis, J., Weigensberg, M., & Goran, M. (2011). Improving insulin resistance in obese youth: Choose your measures wisely. International Journal of Pediatric Obesity, 6, e290-e296 doi: 10.3109/17477166.2010.528766 Read abstract PMID: 21070095

Shaibi, G. Q., Coletta, D. K., Vital, V., & Mandarino, L. J. (2013). The Design and Conduct of a Community‐Based Registry and Biorepository: A Focus on Cardiometabolic Health in Latinos. Clinical and translational science, 6(6), 429-434.